SMA-SH: Modified Styrene–Maleic Acid Copolymer for Functionalization of Lipid Nanodiscs
نویسندگان
چکیده
منابع مشابه
SMA-SH: Modified Styrene-Maleic Acid Copolymer for Functionalization of Lipid Nanodiscs.
Challenges in purification and subsequent functionalization of membrane proteins often complicate their biochemical and biophysical characterization. Purification of membrane proteins generally involves replacing the lipids surrounding the protein with detergent molecules, which can affect protein structure and function. Recently, it was shown that styrene-maleic acid copolymers (SMA) can disso...
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Once removed from their natural environment, membrane proteins depend on membrane-mimetic systems to retain their native structures and functions. To this end, lipid-bilayer nanodiscs that are bounded by scaffold proteins or amphiphilic polymers such as styrene/maleic acid (SMA) copolymers have been introduced as alternatives to detergent micelles and liposomes for in vitro membrane-protein res...
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ژورنال
عنوان ژورنال: Biomacromolecules
سال: 2016
ISSN: 1525-7797,1526-4602
DOI: 10.1021/acs.biomac.6b00140